Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer

Table 3 EQ-5D index-based utility scores by ECOG grade, overall and lung cancer

Cancer Group	ECOG Grade	Utility score	n	Mean	SD	Med	Min	Max	Mean Diff	SEM	0.50 SD	0.33 SD
All	0	UK	122	0.85	0.16	0.85	0.16	1.00		0.09	0.08	0.05
		US		0.89	0.11	0.84	0.51	1.00		0.06	0.06	0.04
	1	UK	258	0.73	0.20	0.74	-0.14	1.00	0.13	0.12	0.10	0.07
		US		0.78	0.14	0.81	0.21	1.00	0.10	0.08	0.07	0.05
	2	UK	133	0.63	0.21	0.69	-0.11	1.00	0.09	0.12	0.11	0.07
		US		0.72	0.14	0.77	0.28	1.00	0.07	0.08	0.07	0.05
	3	UK	21	0.48	0.28	0.52	0.02	1.00	0.16	0.16	0.14	0.09
		US		0.61	0.19	0.60	0.26	1.00	0.11	0.11	0.10	0.06
Mean weighted MID		UK	534						0.12	0.11	0.10	0.07
		US							0.09	0.08	0.07	0.05
Lung	0	UK	9	0.78	0.15	0.73	0.62	1.00		0.08	0.07	0.05
		US		0.83	0.11	0.80	0.71	1.00		0.06	0.05	0.04
	1	UK	29	0.68	0.24	0.80	0.08	1.00	0.10	0.14	0.12	0.08
		US		0.74	0.17	0.82	0.31	1.00	0.09	0.10	0.09	0.06
	2	UK	11	0.55	0.18	0.62	0.29	0.76	0.13	0.10	0.09	0.06
		US		0.67	0.12	0.71	0.45	0.83	0.07	0.07	0.06	0.04
	3	UK	1	0.52	--	0.52	0.52	0.52	0.03
		US		0.60	--	0.60	0.60	0.60	0.07
Mean Weighted MID		UK	50						0.11	0.12	0.10	0.07
		US							0.09	0.08	0.07	0.05

ECOG – Eastern Cancer Oncology Group (grade ranges from level 0 is fully active to level 3, capable of only limited self-care and confined to bed more than 50% of waking hours); MID – minimally important difference; UK – United Kingdom; US – United States; SEM – standard error of the mean; SD – standard deviation

ISSN: 1477-7525