Table 2 Summary of the parameters used in the simulation study and the corresponding values

Number of time points

5 or 10

Time effect

Linear: μ₀ = −0.4 and μ _end  = −0.4

Arm effect

Δ = 0 for T ≥ T₀ or Δ = 0 at T₀; Δ = 0.4 for T > T₀

Correlation between HRQoL measures

0.4; 0.7; 0.9

Number of Patients

100; 200; 300

Items

1; 2; 4

Response Categories per item

4; 7 (only for 2 items, 200 patients)

Percentage of missing data at each follow-up

0; 10%; 20%; 30%