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Table 2 Variables related to anesthesia and surgery and uro-oncological features, presented as numbers (%) or median with interquartile range

From: Health-related quality of life and self-reported cognitive function in patients with delayed neurocognitive recovery after radical prostatectomy: a prospective follow-up study

 

no DNCR

(n = 235)

DNCR

(n = 64)

Surgical technique

  

RARP

107 (45.5)

30 (46.9)

ORP

128 (54.5)

34 (53.1)

Duration of surgery, min

185 (160–210)

193 (163–218)

Estimated blood loss, ml

600 (300–900)

500 (250–900)

Midazolam for premedication

212 (91.4)

61 (95.3)

Anesthetic technique

  

Balanced anesthesia

130 (55.3)

31 (48.4)

TIVA

105 (44.7)

33 (51.6)

Additional spinal anesthesia

60 (20.1)

14 (4.7)

Sufentanil, µga

90 (70–100)

90 (65–100)

High vasopressor supportb

196 (83.4)

52 (81.3)

Duration of anesthesia, min

265 (235–290)

270 (237.5–302.5)

Fluids, mlc

2500 (2000–3000)

2500 (2000–3000)

PSA preoperative, ng/ml

7.2 (5.2–11.2)

7.7 (4.8–12.8)

Neoadjuvant androgen deprivation therapy

11 (4.7)

7 (10.9)

Prostate volume (sonographic assessment), ml

36 (28–50)

44 (29–56)

Prostate volume (histopathologic assessment), ml

25 (20–35)

30.1 (20–45)

Tumor volume, ml

4.6 (2.4–8.4)

5.4 (3.1–12.2)

Resected lymph nodes

14 (8–22)

13 (7–21)

N stage

  

N0

187 (79.6)

42 (65.6)

N1

31 (13.2)

16 (25.0)

Nx

17 (7.2)

6 (9.4)

T stage

  

pT2a-2c

155 (66.0)

32 (50.0)

pT3a-3c

80 (34.0)

32 (50.0)

Gleason scored

  

1

15 (6.4)

4 (6.3)

2

144 (61.3)

33 (51.6)

3

52 (22.1)

15 (23.4)

4

2 (0.9)

0 (0.0)

5

22 (9.4)

12 (18.8)

Positive surgical margin

  

R0

187 (79.6)

43 (67.2)

R1

48 (20.4)

20 (31.3)

Rx

0 (0.0)

1 (1.6)

  1. DNCR delayed neurocognitive recovery, RARP robot-assisted radical prostatectomy, ORP open retropubic radical prostatectomy, TIVA total-intravenous anesthesia, PSA prostate-specific antigen
  2. aTotal dose administered for anesthesia induction and intraoperatively
  3. bHigh vasopressor support was defined as requirement of noradrenaline > 75% of surgical time
  4. cTotal intraoperative amount
  5. dGrading according to the 2014 International Society of Urological Pathology Consensus Conference