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Table 3 PRO instruments identified in trials with NNRTIs

From: Patient reported outcome instruments used in clinical trials of HIV-infected adults on NNRTI-based therapy: a 10-year review

Instrument type and name

Study count

Instruments measuring quality of life

 

 Generic

 

  SF-36 (v2)

2

  SF-12 (v2)

2

  EORTC QLQ-30

1

  Illness Intrusiveness Rating Scale (IIRS)

2

  Istituto Superiore di Sanità Quality of Life (ISSQoL)

1

 HIV-targeted

 

  Medical Outcomes Study HIV (MOS-HIV)

81

  Functional Assessment of HIV Infection (FAHI)

3

  World Health Organization Quality of Life (WHOQOL)-HIV BREF

1

Instruments measuring symptoms

 

 General HIV symptoms

 

  HIV Symptom Index (HIV-SI) /AIDS Clinical Trials Group Symptom Distress Module (SDM)

32

 Sleep

 

  Pittsburgh Sleep Quality Index (PSQI)

2

  Epworth Sleep Score (ESS)

2

  Stanford Sleepiness Scale (SSS)

2

  Groningen Sleep Quality Score (GSQS)

2

  Oviedo Sleep Questionnaire (OSQ)

1

 Anxiety (only)

 

  Hamilton Anxiety Rating Scale (HAM-A)

1

  State-Trait Anxiety Inventory for Adults (STAI)

1

 Depression (only)

 

  Centers for Epidemiological Studies-Depression (CES-D)

3

  Beck Depression Inventory-2nd edition (BDI-II)

1

  Hamilton Depression Rating Scale (HAM-D)

1

 Anxiety and depression (only)

 

  Hospital Anxiety and Depression Scale (HADS)

1

 Anxiety, depression, and stress

 

  Depression Anxiety and Stress Scale-short version (DASS21)

1

 Psychiatric symptoms

 

  Positive and Negative Syndrome Scale (PANSS)

1

  Positive and Negative Suicide Ideation (PANSI)

1

  Symptom Checklist-90 (SCL-90) - Somatization Subscale

1

  Body Image Impact scale

1

Instruments measuring beliefs about medications

 

  Beliefs about Medicines Questionnaire-ART version (BMQ-ART)

2

  HAART Intrusiveness Scale

2

  1. 12 additional studies used modified versions of the MOS-HIV; 22 additional studies used the ACTG Adherence Questionnaire, which contains the HIV-SI/SDM.